Mucoadhesive drug delivery system adhesion polymers. The major categories are wetting theory, adsorption theory, diffusion theory, electrostaticic theory, and fracture theory. The use of mucoadhesive polymers in buccal drug delivery has a greater application. Sushma gopal sree dattha institute of pharmacy, sheriguda, ibrahmipatnum, hyderabad abstract the main objective of present study was to design and evaluate the muco adhesive buccal. Buccal patchesfilms they are long, flat, thin thickness, transparent. Mucoadhesion involves several types of bonding mechanisms, and it is the interaction between each process that allows for the adhesive process.
Overview and future potential of buccal mucoadhesive films as. Formulation and evaluation of mucoadhesive buccal patch. The patch may contain a mucoadhesive polymer layer which bonds to the oral mucosa, gingiva, or. Overview on buccal drug delivery systems journal of. All fabricated film formulations prepared were smooth and translucent, with good flexibility. Buccal mucoadhesive drug delivery buccal or sublingual regions within oral cavity can be used for systemic delivery of drugs. Ppt buccal drug delivery system powerpoint presentation. Formulation and evaluation of mucoadhesive buccal patches of labetalol. Buccal mucoadhesive tablets are dry dosage forms that have to be moistened prior to placing in contact with buccal mucosa. Striant mucoadhesive system, extended release 12 hr webmd. Mucoadhesive patch were weighed individually x 0 and placed separately in 2% agar gel plates and incubated at 370c10c. Mucoadhesive drug delivery system is a part of controlled delivery system. A piece of porcine buccal mucosa was glued on a support and kept in a vessel placed in a thermostatic bath at 37 c 0. Ann rose augusthy 1, vipin k v 2, sarath chandran c 2, muhammed nizar av 2, and sreeraj k 3.
Preparation of buccal mucoadhesive controlled drug delivery systems of. Seminar on buccal drug delivery systum last modified by. How to use striant mucoadhesive system, extended release 12 hr. The patches were packed in an aluminum foil and stored in an airtight glass container to maintain the integrity and elasticity of the patches. Bilayerd films were prepared by solvent casting technique using different concentration of two polymers namely, sodium alginate and pectin. The weight and thickness of all the formulations were found to be uniform. How one can evaluate mucoadhesive buccal formulation. Design and characterization of mucoadhesive buccal patches containing cetylpyridinium chloride. Novel drug delivery systems ndds are the system where the man searches for new methods of entry of drugs in to the body in order to show its activity in the body. Find powerpoint presentations and slides using the power of, find free presentations research about oral mucosa histology ppt. Discuss the merits and demerits of mucoadhesive buccal drug delivery. Aug 06, 2012 formulation and evaluation of mucoadhesive buccal patches of labetalol. Formulation and evaluation of mucoadhesive buccal patches of.
Buccal or sublingual regions within oral cavity can be used for systemic delivery of drugs. Sushma gopal sree dattha institute of pharmacy, sheriguda, ibrahmipatnum, hyderabad abstract the main objective of present study was to design and evaluate the muco adhesive buccal patch. Read the patient information leaflet provided by your pharmacist before you start using testosterone and each time you get a refill. Overview and future potential of buccal mucoadhesive films. For mucoadhesive measurements, films were cut in portions of 4 cm 2 and pasted on a support, connected to the dynamometer lehrmittelban, professor dr. The formulations were tested for in vitro drug permeation studies, buccal absorption, in vitro drug release studies, moisture absorption as well as for in vitro and in vivo bioadhesion. Apr 10, 20 administering the drug via membrane located below the tongue is called sublingual ddssldds generally called floor of mouth. Formulation and evaluation of buccal patches of diclofenac sodium shubhra pandey abstract. Mucoadhesive preparations contain one or more active substances intended for systemic absorption through the buccal mucosa over a prolonged period of time. Enalapril maleate is used in the treatment of hypertension and angina pectoris. Permeation of ond was calculated ex vivo using porcine buccal membrane.
They can be prepared by two methods solvent casting method direct milling method department of pharmaceutical technology,41020 lj institute of pharmacy, ahmedabad 31. Free download corneal abrasions powerpoint presentation slides. Mucoadhesive buccal patches containing venlafaxine were prepared using the solvent casting method. It shows low bioavailability due to high hepatic first pass metabolism. Formulation and evaluation of buccal patches of simvastatin by using different polymers shalini mishra1, g. Films can circumvent the difficulty of the relatively short. Buccal patchesfilms they are long, flat, thin thickness, transparent with high surface area. Formulation and evaluation of mucoadhesive buccal film of lisinopril. The sldds is almost similar to the bdds having some more advantages than buccal drug delivery system. Formulation and evaluation of mucoadhesive buccal film of.
The buccal patches were prepared using the solvent casting method. Buccal route is an attractive route of administration for systemic drug delivery. Formulation and evaluation of buccal patches for delivery of. Theories, polymers, dosage forms, evaluation of mucoadhesive dosage forms. Like buccal cavity, nasal cavity also provides a potential site for the development of formulations where mucoadhesive polymers can play an important role. The present study involves the formulation and evaluation of buccal tablets of glipizide, an antidiabetic drug has. Development of mucoadhesive patches for buccal administration. Formulation and evaluation of mucoadhesive buccal films of. Formulation and evaluation of mucoadhesive buccal patch of.
A trilaminate film suitable for prolonged and sustained delivery of an active ingredient in a buccal cavity is disclosed. A hydratable mucoadhesive base layer, a nonadhesive reservoir layer and a waterimpermeable carrier film sandwiched between and bonded to the base layer and the reservoir layer are the elements which form the trilaminate film. Mucoadhesive buccal patches based on interpolymer complexes. Buccal films of ondanstron hydrochloride were fabricated from mucoadhesive polymer, chitosan, and polyvinyl pyrrolidone pvp k30 for the purpose of prolonging drug release and improving its bioavailability. Patchesfilms liquid buccal adhesive dosage form viscous liquids mucoadhesive buccal films various mucoadhesive devices has been formulated like tablets,27 patches, 28 devices, strips,29 ointments,30 gels, 31 26 disks. The drug containing layer was prepared by using pectin. Ann rose augusthy 1, vipin kv 2, sarath chandran c 2, thushara mv 2, shahin muhammed tk 3. They adhere to buccal mucosa for extended period of time. Hence the present work was undertaken to formulate mucoadhesive buccal films of enalapril maleate with an objective to improve therapeutic efficacy, patient compliance and the bioavailability. Attention towards mucoadhesive buccal drug delivery system. They can be prepared by two methods solvent casting method direct milling method 32020 31 department of pharmaceutical technology, lj institute of pharmacy, ahmedabad.
Formulation and evaluation of buccal patches of simvastatin. The mucoadhesive buccal drug delivery system offers several advantages as compared to traditional methods of systemic drug administration 2, 3. Buccal adhesive patches are modified release dosage form that have potential to provide controlled drug delivery from 1 to 24 hrs. The backing membrane was prepared by using sodium alginate. What are the objectives of sublingual drug delivery system. Buccal bioadhesive films, releasing topical drugs in the oral cavity at a slow and.
An approach to prepare buccal patches using chitosan and hpmc polymers. Formulation and evaluation of buccal patches for delivery. Mucoadhesive buccal tablets are prepared by compression of mono or multi. Formulation and evaluation of buccal patches of diclofenac sodium. Buccal drug delivery system authorstream presentation. If so, share your ppt presentation slides online with. He used hpmc e 15 as main polymer for preparation of buccal patch using solvent casting method. The uploader spent hisher valuable time to create this corneal abrasions powerpoint presentation slides, to share hisher useful content with the world. Buccal formulationbuccal tablets buccal patches most commonly investigated laminates consisting of an dosage form for buccal drug impermeable backing layer, a tablets are small, flat, and oval, drugcontaining reservoir layer, a with a diameter of approximately bioadhesive surface for mucosal 58 mm attachment tablets can be. Mucoadhesive drug delivery system ppt linkedin slideshare. View and download powerpoint presentations on oral mucosa histology ppt. Adhesive polymer itself act as drug carrier or adhesive layer link between drug loaded layer. Pdf buccal tablet as a promising mucoadhesive drug delivery. Apr 15, 2016 the buccal mucosa is a barrier, providing protection to underlying tissue, but is more permeable than other alternative routes such as the skin.
Describe methods to determine muco adhesion property of formulations. A slow release bioadhesive lozenge offers the potential for. Literature studies on preparation and evaluation of buccal. Patel nagar, dehradun, uttarakhand248001, india the objective of this study was to develop mucoadhesive buccal tablets of simvastatin using mucoadhesive polymers. He formulates the optimum patch having 2500 mg of hpmc e15. Mucoadhesive buccal patches of carvedilol were prepared using solvent casting method. Moreover, buccal patches provide more flexibility than other drug deliveries. The use of mucoadhesive polymers in buccal drug delivery has a great applications. Dosage forms designed for mucoadhesive drug delivery should be small and. Jun 09, 2010 the buccal cavity is easily accessible for self medication, and hence it is safe and well accepted by patients, since buccal patches can be very easily administered and even removed from the application site, terminating the input of drug whenever desired. Three different polymers were used hpmc k4m, hpmc k15m and scmc, along with plastisizer peg 400 and a hydrophilic polymer pvp k30, so that the patch could be made pliable.
The substrate possessing bioadhesive polymer can help in drug delivery for a prolonged period of. Formulation and evaluation of buccal patches of diclofenac. Preparation of mucoadhesive patches for buccal administration. The study was designed to develop bioadhesive patches of carvedilol hydrochloride using chitosan ch and pectin pe interpolymer complexes and to systematically evaluate their in vitro and in vivo performances. Buccal films are polymeric matrices designed to be mucoadhesive properties and usually formulated with permeability enhancers to. Mucoadhesive drug delivery system free ebook download as powerpoint presentation.
View and download powerpoint presentations on buccal cavity ppt. Find powerpoint presentations and slides using the power of, find free presentations research about buccal cavity ppt. Scribd is the worlds largest social reading and publishing site. This makes the buccal cavity more suitable for mucoadhesive drug delivery6. Administering the drug via membrane located below the tongue is called sublingual ddssldds generally called floor of mouth. Sometime buccal drug delivery system has required permeation enhancer to overcome problem. Various mucoadhesive devices, including tablets, films, patches, disks, strips, ointments and gels, have recently been developed. Two methods used to prepare adhesive patches include solvent casting and direct milling. Patches films liquid buccal adhesive dosage form viscous liquids mucoadhesive buccal films various mucoadhesive devices has been formulated like tablets,27 patches, 28 devices, strips,29 ointments,30 gels, 31 26 disks.
Buccal patches buccal patch is a nondissolving thin matrix modifiedrelease dosage form composed of one or more polymer films or layers containing the drug andor other excipients. Buccal films are polymeric matrices designed to be mucoadhesive properties and usually formulated with permeability enhancers to improve bioavailability. The dried films were cut into square pieces of sides 1. The new drug delivery systems that have been developed and developing are the mucoadhesive drug delivery systems, drug patches, transdermal patches etc.
Buccal mucoadhesive tablets are dry placing in contact with buccal mucosa. They may be supplied as mucoadhesive buccal tablets or as other mucoadhesive solid or semisolid preparations. Formulation and evaluation of mucoadhesive buccal patches. Moreover, in the case of local delivery for oral diseases, the films also help. Chitosan and pectin were used as bioadhesive polymer and different ratios. Formulation and evaluation of rabeprazole buccal patches. Buccal patches films they are long, flat, thin thickness, transparent with high surface area. The mucoadhesive buccal patches were prepared by solvent casting technique using two different mucoadhesive polymers. Development of mucoadhesive patches for buccal administration of ibuprofen. Generally factors affecting the sldds are almost similar to factors related with the bdds. Table 1 shows the composition of formulated buccal patches. Buccal patch film buccal patch film are laminates consisting of an impermeable backing layer, a drugcontaining reservoir layer from which the drug is released in a controlled manner, and a bioadhesive surface for mucosal attachment.
The formulations were tested for in vitro drug permeation studies, buccal absorption, in vitro drug release studies, moisture. For example, compacts have been used for drug delivery to the oral. The buccal mucosa is a barrier, providing protection to underlying tissue, but is more permeable than other alternative routes such as the skin. The patches were evaluated for their physical characteristics like mass variation, drug content uniformity, folding. The buccal cavity is easily accessible for self medication, and hence it is safe and well accepted by patients, since buccal patches can be very easily administered and even removed from the application site, terminating the input of drug whenever desired. Specific processes include mechanical interlocking, electrostatic, diffusion interpenetration, adsorption. Measurement of mucoadhesive strength20,21 exvivo mucoadhesive strength of metoprolol tartrate buccal tablets. However, buccal patch offer greater flexibility and comfort than the other devices. Casein, the major milk protein, comprises about 80 % total protein. Buccal drug delivery free download as powerpoint presentation. In vitro and in vivo evaluation of chitosan buccal films. The buccal mucosa is an attractive route for systemic delivery of many drugs since it is relatively permeable with a rich blood supply.
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